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Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide
Annals of Hematology, 09/17/08

Palladini G et al. - Treatment with melphalan, thalidomide, and reduced intensity dexamethasone (MTD) is feasible in patients with advanced cardiac AL amyloidosis and effective in subjects with preserved systolic function.

• Aim was to see if pts with advanced cardiac AL can tolerate aggressive therapy
• 22 pts were treated with combining oral melphalan, thalidomide, and reduced intensity dexamethasone (MTD)

• 6 pts died due to cardiac amyloidosis before completing cycle 3
• Early death was associated with reduced ejection fraction
• 8 pts achieved a hematological response and 4 a durable improvement of cardiac dysfunction

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