Rheumatology Medical News about chondroitin sulfate;joint swelling

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Potential effects of chondroitin sulfate on joint swelling: A GAIT report
Osteoarthritis and Cartilage , 09/05/08

Hochberg MC et al. - An analysis of Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) patients suggested the effect of chondroitin sulfate on joint swelling occurred more often in patients with milder pain and lower Kellgren–Lawrence Grade at entry.

Methods

GAIT- a 24-wk, double-blind randomized placebo-controlled trial comparing glucosamine, chondroitin sulfate, and the two in combination in treating knee pain in pts (n=1583) with knee OA
Pts were randomized into placebo, glucosamine 500 mg x3/d, chondroitin sulfate 400 mg x3/d, combination in the same dosages or celecoxib 200 mg/d

Results

Pts on celecoxib had improvement in knee pain vs placebo
No improvement in knee pain was seen among pts randomized to the dietary supplements
Pts with moderate-to-severe pain receiving combination experienced some improvement
Pts taking chondroitin sulfate had improvement in knee joint swelling

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