Rheumatology Medical News about rheumatoid arthritis;rituximab

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab
Arthritis Research & Therapy, 09/05/08

Rosengren S et al. – Combined with earlier observations that synovial lymphoid aggregates survived rituximab treatment, these data suggest that lymphoid aggregates may provide a protective niche for autoantibody producing cells.

Methods

Study to evaluate the contribution of synovial lymphoid aggregates to autoantibody, total immunoglobulin production in RA pts, and the effect of the B-cell depleting ab, rituximab
Autoantibodies, total IgM and IgG were quantified by ELISA in extracts of synovial tissues and matched serum
Synovial biopsies and serum were obtained at baseline and 8 wks following rituximab therapy in 14 RA pts

Results

Anti-CCP IgG, but not RF-IgM, was enriched in RA synovia vs serum
Total IgM and IgG was also enriched in RA, but not in OA
SSI correlated with mRNA content for both IgM and IgG
RA synovia with lymphocyte aggregates contained elevated RF-IgM and anti-CCP IgG vs tissues with diffuse lymphoid infiltration
Rituximab treatment did not affect synovial autoantibody or total Ig SSI overall
In aggregate-containing tissues, rituximab reduced total IgM and IgG SSI as well as IgM and IgG1 mRNA
RF-IgM and anti-CCP IgG synovial/serum indices were unchanged by rituximab in aggregate-containing synovial

<< Previous
Disease activity and the course of wrist joint deterioration over...

Next >>
Upregulated miR-146a expression in peripheral blood mononuclear...

Efficacy of roxithromycin in adult patients with rheumatoid arthritis who had not received disease-modifying antirheumatic drugs: A 3-month, randomized, double-blind, placebo-controlled trial
Clinical Therapeutics, 10/15/09 Relevance Score: 71%%

Certolizumab Pegol: In Rheumatoid Arthritis
BioDrugs, 11/11/09 Relevance Score: 70%%

Assistive technology for rheumatoid arthritis
Cochrane Reviews, 10/09/09 Relevance Score: 70%%

Treatment of early RA with infliximab is beneficial
American Pharmacists Association, 11/06/09 Relevance Score: 69%%

Abatacept for rheumatoid arthritis
Cochrane Reviews, 10/09/09 Relevance Score: 69%%