Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells
Arthritis Research & Therapy, 09/05/08
Santos SG et al. – HLA-B27 heavy chain dimer formation can be induced upon dendritic cell activation, implying that these novel structures may not be displayed to the immune system at all times. Thus the behaviour of HLA-B27 on dendritic cells may be important in the study of inflammatory arthritis.
Methods- Aim was to study the formation of HLA-B27 heavy chain homodimers in dendritic cells
- Cell lines studied: dendritic like cell lines and monocyte derived dendritic cells from peripheral blood
- The KG-1 dendritic-like cell line was transfected with HLA-B27 cDNA constructs
- Cellular distribution, intracellular assembly and ability of HLA-B27 to form heavy chain homodimers vs human monocyte-derived dendritic cells after stimulation with LPS was studied
- Cells expressing HLA-B27 display an intracellular source of MHC class I heavy chain partially overlapping with the Golgi, but not the endoplasmic reticulum, was lost upon cell maturation with PMA and ionomycin
- Formation of HLA-B27 homodimers was induced upon maturation, with a transient induction also seen in LPS stimulated human monocyte-derived dendritic cells expressing HLA-B27
- The weak association of wildtype HLA-B*2705 with the transporter associated with antigen processing (TAP) could also be enhanced by mutation of residues at position 114 and 116 in the peptide-binding groove to those present in the HLA-B*2706 allele
Related Articles
Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor
Modern Rheumatology, 10/05/09
Relevance Score: 69%
Erythrocyte sedimentation rate, CRP level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
Arthritis Care and Research, 11/02/09
Relevance Score: 68%
Uncommon case of ankylosing spondylitis associated with spontaneous occurring hypoparathyroidism
Rheumatology International, 11/11/09
Relevance Score: 67%
Concomitant cervical and thoracic spinal fractures in ankylosing spondylitis: A case report and review of literature
Injury Extra, 11/05/09
Relevance Score: 67%
A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitis
Rheumatology International, 10/27/09
Relevance Score: 67%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Increased mRNA expression of collagen V gene in pulmonary fibrosis of systemic sclerosis
European Journal of Clinical Investigation, 12/04/09
The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome
Rheumatology, 12/01/09
Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells
Modern Rheumatology, 12/01/09
Today in Other Arthritis...keeping you current
Receive free subspecialty "5-minute updates" via email
Long-term experience with etanercept in psoriatic arthritis patients: A 3-year observational study
Journal of Dermatological Treatment , 12/04/09
Modeling the need for hip and knee replacement surgery. Part 1. A two-stage cross-cohort approach
Arthritis Care and Research , 12/03/09
Identification of undiagnosed inflammatory arthritis in a community health fair screen
Arthritis Care and Research , 12/02/09
Sponsor
Article Search
Sponsor


See Latest Articles


