Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
Arthritis Research & Therapy, 09/05/08
Pauley KM et al. – MicroRNA (miRNA) expression in RA peripheral blood mononuclear cells mimics that of synovial tissue/fibroblasts, thus may serve as a potential useful marker for disease diagnosis, progression, or treatment efficacy.
Methods- Aim was to study the expression of selected miRNA in RA
- Total RNA isolated from peripheral blood mononuclear cells of pts, healthy, and disease controls were applied for the expression of miR-146a, miR-155, miR-132, miR-16, and microRNA let-7a
- RA cells exhibited between 1.8-2.6 fold increase in miR-146a, miR-155, miR-132, and miR-16 expression
- MicroRNA let-7a expression was not different vs healthy controls
- Two targets of miR-146a, TRAF6 and IRAK-1, were similarly expressed in RA pts and controls, despite the increased expression of miR-146a in RA pts
- Repression of TRAF6 and/or IRAK-1 in THP-1 cells resulted in up to 86% reduction in TNF-α production
- This implicated that normal miR-146a function is critical for the regulation of TNF-α production
| Previous Article | Next Article |
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Global vitamin D status and determinants of hypovitaminosis D
Osteoporosis International, 06/25/09
The detecting and clinical value of anti-cyclic citrullinated peptide antibodies in patients with systemic lupus erythematosus
Lupus, 06/10/09
CSF levels of cytokines in neuro-Behçet's disease
Clinical Neurology and Neurosurgery, 06/11/09
Today in Rheumatoid Arthritis...keeping you current
Receive free subspecialty "5-minute updates" via email
Denosumab update
Current Opinion in Rheumatology, 06/11/09
Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor-alpha inhibitors (GO-AFTER study): A multicentre, randomised, double-blind, placebo-controlled, phase III trial
The Lancet - Early Online Publication, 07/01/09
Masitinib in the treatment of active rheumatoid arthritis: Results of a multicentre, open-label, dose-ranging, phase 2a study
Arthritis Research & Therapy, 06/25/09
Sponsor
Article Search
Sponsor


See Latest Articles


