Rheumatology Medical News about rheumatoid arthritis;upregulated miR-146a expression

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Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
Arthritis Research & Therapy, 09/05/08

Pauley KM et al. – MicroRNA (miRNA) expression in RA peripheral blood mononuclear cells mimics that of synovial tissue/fibroblasts, thus may serve as a potential useful marker for disease diagnosis, progression, or treatment efficacy.

Methods

Aim was to study the expression of selected miRNA in RA
Total RNA isolated from peripheral blood mononuclear cells of pts, healthy, and disease controls were applied for the expression of miR-146a, miR-155, miR-132, miR-16, and microRNA let-7a

Results

RA cells exhibited between 1.8-2.6 fold increase in miR-146a, miR-155, miR-132, and miR-16 expression
MicroRNA let-7a expression was not different vs healthy controls
Two targets of miR-146a, TRAF6 and IRAK-1, were similarly expressed in RA pts and controls, despite the increased expression of miR-146a in RA pts
Repression of TRAF6 and/or IRAK-1 in THP-1 cells resulted in up to 86% reduction in TNF-α production
This implicated that normal miR-146a function is critical for the regulation of TNF-α production

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