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Biochemical markers of bone turnover and their association with bone marrow lesions
Arthritis Research & Therapy, 09/05/08

Hunter DJ et al. – Serum Type I Collagen N-telopeptide (NTx) was weakly associated with bone marrow lesions (BML) presence in both study samples as reported in this trial. Since this relationship was not strong their use as markers for the presence of BMLs is not recommended.

Methods

Aim was to determine if markers of bone resorption and formation could serve as markers for the presence of BMLs
Knee MR images were scored for BMLs
In addition, a subset of persons with BMLs had a quantitative volume measure of their BML
Bone biomarkers assayed included NTx/ Cr, Bone Specific Alkaline Phosphatase (BSAP), and Osteocalcin (OST)

Results

151 subjects with knee OA were assessed from the first study
The mean (SD) age was 67 (9) years and 60% were male
69% had maximum BML score >0, 48% had maximum BML score >1
LnNTx demonstrated an association with the odds of a bone marrow lesion being present increased 1.4 fold per SD increase in the Ln NTx
55% of participants from another study had a maximum BML score >0
The relationship between NTx and maximum score of BML>0 revealed an association with OR=1.7 after adjusting for age, sex and BMI