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Clinical outcome in children with chronic recurrent multifocal osteomyelitis
Rheumatology, 08/27/08

Catalano-Pons C et al. – Clinical outcome of children with chronic recurrent multifocal osteomyelitis (CRMO) is generally good, but a sizeable proportion of patients have active disease at follow-up, and a minority of patients can have a severe and prolonged disease course despite intensive treatments.

Methods

Aim was to determine the clinical outcome of children with CRMO
Clinical, biological and radiological data of children with CRMO was reviewed
Outcome data were obtained through review of hospital charts and questionnaires sent to all pts

Results

40 pts were assessed with a median age at diagnosis of 11.5 yrs
Median number of initial bony lesions was 2 at onset, and 3.5 over disease course
Median time since diagnosis was 3.5 yrs and median duration of active disease 2.7 yrs
9 (22.5%) pts had psychological or physical sequelae
29 children (72.5%) responded to the questionnaire
26 had no physical disability, 2 had moderate disability and 1 had severe disability
17 pts (58.6%) had active disease at f/u and continued to have pain
CRMO had interfered with patient's education in two cases

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