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Cartilage biomarkers in hemodialysis patients and the effect of β2-microglobulin on articular chondrocytes
Osteoarthritis and Cartilage , 08/08/08

Sunk IG et al. – β2-microglobulin (β2m) exerted anti-anabolic effects on articular chondrocytes in vitro and might be involved in cartilage degradation in HD patients. β2m serum levels, however, did not reflect cartilage degradation in dialysis-related amyloidosis (DRA). The assessment of C2C/CPII, CS-486 or COMP concentrations apparently has minor relevance in DRA diagnosis in HD patients.

• Study to investigate the significance of β2m and its relationship to distinct cartilage biomarkers in early DRA diagnosis in HD pts
• Effects of β2m on articular chondrocytes in vitro were also assessed
• Serum samples from 133 pts were collected before and after HD
• Type II collagen cleavage product (C2C), procollagen II c-propeptide (CPII), aggrecan chondroitin sulfate 846 epitope (CS-486) and cartilage oligomeric matrix protein (COMP) levels were determined by ELISA
• Cartilage glucosaminoglycan synthesis was measured by [³⁵S]sulfate incorporation
• mRNA expression of IL-1β, MMPs-3 and -9 was measured by RT-PCR

• Incubation with β2m at 20 mg/l decreased matrix biosynthesis
• An increase of IL-1β, as well as MMPs-3 and -9 on the mRNA level was observed
• C2C/CPII, CS-486 and COMP levels were increased only in a subset of pts w/o a correlation with β2m concn
• A subgroup analysis elucidated an increase in type II collagen degradation during the first yrs of HD, as shown by the elevation of C2C/CPII ratio

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