Oka H et al. - Knee OA computer-aided diagnosis (KOACAD) was shown to be useful for objective, accurate, simple and easy evaluation of the radiographic knee OA severity in daily clinical practice. This system may also serve as a surrogate measure for the development of disease-modifying drugs for OA, just as bone mineral density does in osteoporosis. Methods
Aim was to establish a fully automatic program KOACAD to quantify the major OA parameters on plain knee radiographs
KOACAD was programmed to measure joint space narrowing at medial and lateral sides, osteophyte formation, and joint angulation
Anteroposterior radiographs of 1979 knees were analyzed by KOACAD and conventional categorical grading systems
Results
KOACAD automatically measured all parameters in less than 1 s without intra- or interobserver variability
All parameters, especially medial joint space narrowing, were correlated with the conventional gradings
In the parameters, osteophyte formation was associated with none of the joint space parameters
Medial joint space narrowing and varus angulation of knee joints were risk factors for the presence of pain while neither lateral joint space nor osteophyte area was
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