Milliken LA et al. - Body composition changes are important positive predictors of BMD changes independent of EX and CA supplementation, but their contribution varies according to bone site and with HT use. Methods
Study to examine the relationship between changes in body weight and composition and changes in 4-year BMD after accounting for age, exercise, and calcium supplement intake (CA) in postmenopausal women with and w/o hormone therapy
Postmenopausal women (aged 40–65 yrs) either using HT (for 1–3.9 yrs) or not using HT (for ≥1 year) were recruited to the study
EX and CA was monitored throughout the study and 167 women completed 4 yrs
BMD and soft tissue composition measurements were made using dual-energy X-ray absorptiometry
Regression was used to predict 4-yr BMD changes from EX, CA, age, baseline and 4-yr changes in body weight and composition
HT users, and non-users were analyzed separately
Results
The models predicting regional BMD changes that included soft tissue composition changes explained the most variation vs those with body weight or EX and CA alone
Larger amounts of variation in BMD changes were explained in the no HT group
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