Schett G et al. - This review examines the function of one key signal transduction pathway of inflammation—the p38 mitogen-activated protein kinases (p38MAPK).
The signalling pathway is considered as crucial for the induction and maintenance of chronic inflammation
This review not only summarises the current knowledge of activation, regulation and function of the p38MAPK pathway but also examines the role of this pathway in clinical disease
It gives an overview of current evidence of p38MAPK activation in inflammatory arthritis and elaborates the key molecular determinants which contribute to p38MAPK activation in joint disease
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