Mukhtyar C et al. - Factors influencing remission, relapse, renal and overall survival include the type of immunosuppressive therapy used, pattern of organ involvement, presence of ANCA, older age and male gender. Methods
A systematic literature review for conducting clinical trials in anti-neutrophil cytoplasm antibody associated vasculitis (AAV), and to assess the quality of evidence for outcome measures in AAV
Using a systematic Medline search, the identified studies were categorized according to diagnoses
Factors affecting remission, relapse, renal function and overall survival were identified
Results
A total of 44 papers were reviewed from 502 identified
There was considerable inconsistency in definitions of end points
Remission rates varied from 30%-93% in Wegener granulomatosis (WG), 75% to 89% in microscopic polyangiitis (MPA) and 81% to 91% in Churg–Strauss syndrome (CSS).
The 5-yr survival for WG, MPA and CSS was 74–91%, 45–76% and 60–97%
Relapse was common in the first 2 yrs but the frequency varied: 18% to 60% in WG, 8% in MPA, and 35% in CSS
The rate of renal survival in WG varied from 23% at 15 mos to 23% at 120 mos
Methods used to assess morbidity varied between studies
Ignoring the variations in definitions of the stage of disease, factors influencing remission, relapse, renal and overall survival included immunosuppressive therapy used, type of organ involvement, presence of ANCA, older age and male gender
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