Albers HM et al. - Apart from being a well replicated risk factor for RA, TRAF1/C5 also appears to be a risk factor for the RF negative polyarthritis subtype of JIA and, more generally, seems to be associated with subtypes of JIA characterized by a polyarticular course. Methods
Aim was to investigate the association of the TRAF1/C5 region with the susceptibility to JIA
A case-control association study was performed in 338 Caucasian JIA pts and 511 healthy individuals
SNP rs10818488 as a marker for the TRAF1/C5 region was genotyped
Results
The A-allele was associated with the susceptibility to RF negative polyarthritis with an 11% increase in allele frequency
This association was stronger when combining subtypes with a polyarticular phenotype
A trend towards an increase in A-allele frequency in pts with extended oligoarthritis vs persistent oligoarthritis was observed
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