Borba VZC et al. – This study reports that systemic lupus erythematosus (SLE) patients demonstrate changes in bone remodeling strongly related to disease activity. A high prevalence of 25OHD deficiency was observed in these patients, indicating the need for vitamin D replacement. Methods
Study to investigate effects of SLE disease activity on bone metabolism, their relation to inflammatory cytokines and vitamin D levels
36 SLE pts were classified according to SLEDAI in high activity or in minimal activity, and were compared with normal controls
Serum calcium, phosphorus, parathyroid and sex hormones, bone remodeling markers, IL-6, sIL-6R, IL-1, TNF-α 25OHD, and 1,25-dihydroxyvitamin D3 were measured, plus BMD
Results
All cytokines were higher in SLE groups
IL-6 could differentiate SLE pts from controls
In group I, 25OHD levels were lower which was related to the SLEDAI
25OHD level was associated with SLEDAI, osteocalcin and bone-specific alkaline phosphatase
The SLEDAI score was positively correlated with all measured cytokines and especially TNF
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