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Click the title below to leave the MDLinx Network and go to the Journal's Website
Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Revealed by a Comprehensive Analysis of the CCN Family Proteins in Cartilage
Journal of Bone and Mineral Research, 07/11/08
Print     Email This Article     Save in My Library   Free Abstract
Kawaki H et al. - Findings collectively indicate that CCN2 induces chondrocyte differentiation by regulating the expression of chondrocyte-associated genes, but that these effects are counteracted by CCN3. The lack of CCN2 caused up-regulation of CCN3 in CCN2-null mice, which resulted in the observed phenotypes, such as the resultant delay of terminal differentiation.
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