Gilliam BE et al. - Importance of measuring IgM RF and IgA RF by ELISA and anti-CCP antibodies by ELISA is demonstrated in this study in addition to COMP in the assessment of JIA patients to determine severity of disease. Methods
Study to evaluate in JIA pts (n=68) a biomarker panel of anti-CCP abs, cartilage oligomeric matrix protein (COMP), CRP, ESR, IgM, RF, IgG RF, and IgA RF to evaluate aggressive disease
All RF isotypes, anti-CCP abs, and COMP were measured by ELISA
Differences and associations were assessed for each biomarker in relation to JE, JSN, and synovitis
Variables were found associated with joint damage and synovitis
Results
Pts with JE and JSN had an elevated levels of IgA RF, IgM RF, and anti-CCP abs
COMP levels were higher in early disease, but also later in disease in pts with no JE or JSN
ESR, CRP, and IgA RF were elevated in pts with active synovitis
IgM RF and disease duration were associated with JE and JSN
Anti-CCP abs and COMP were also associated with JSN. CRP and IgA RF were associated with synovitis
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