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See Latest ArticlesSerum procalcitonin for discrimination between septic and non-septic arthritis
Clinical and Experimental Rheumatology Online, 07/02/08
Hügle T et al. – Procalcitonin (PCT) seems to be a highly sensitive and specific marker for septic arthritis, depending on the clinical setting. Further studies are warranted.
Methods- Study to investigate the diagnostic value of PCT in pts with septic and non-septic arthritis using a novel test with low detection limit
- 42 pts, 28 with non-septic and 14 with septic arthritis were prospectively included
- For each patient, gram stain, culture and polarization microscopy of synovial fluid was done
- PCT, CRP, white blood cell count, uric acid and blood cultures were taken
- Pts with septic arthritis, with non-septic arthritis with and w/o concomitant infection were compared
- Pts with septic arthritis had a higher PCT concn than pts with non-septic arthritis
- At a cut-off of 0.1 (0.25) ng/ml, sensitivity for septic arthritis was 100(93)% and specificity 46(75)%
- Specificity rose to 93% after exclusion of pts with non-septic arthritis and concomitant infection
- Both sensitivity and specificity for the diagnosis of septic arthritis were higher for PCT than CRP
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