Conrozier T et al. – Hip OA, in patients with multiple sites OA (MSOA), might be related to alteration in type II collagen (CII) metabolism which may result in a deficient type II collagen repair process. Methods
Study to determine whether there are detectable differences in and relationships between biomarkers of CII degradation and synthesis in pts with only hip OA (OHOA) and those suffering from MSOA
56 pts classified as MSOA or OHOA
Minimum hip joint space width (Min JSW) measured by computer from standard radiographs
Serum measurement of CII synthesis C-propeptide (CPII) and cleavage of type II (C2C) and types I and II (C1, 2C) collagens
Aggrecan metabolism was assessed by serum CS 846 assay
Results
24 subjects were classified with MSOA
15/32 OHAO pts had bilateral hip OA and 17 had unilateral hip OA
The latter were classified with “Isolated hip OA” (IHOA)
CPII levels were lower in pts with MSOA vs those with OHOA
C2C levels were also lower in MSOA vs OHOA
An inverse correlation between min JSW and C2C only in pts with IHOA
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