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Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis
Osteoarthritis and Cartilage , 07/01/08

Wang WZ et al. – Differences between Kashin–Beck disease (KBD) cartilage and the normal exhibited a similar pattern among the four pairs examined, indicating the presence of common mechanisms mainly including chondrocyte metabolism and apoptosis that contribute to cartilage destruction in KBD.

• Study to investigate the differences in gene expression profiles of adult articular cartilage with endemic OA, KBD, and the same regions in the normal joint
• mRNA expression profiles of articular cartilage with KBD were compared with the normal cartilage
• Total RNA isolated separately from 4 pairs of the KBD and normal cartilage samples were evaluated by oligonucleotide microarray analysis
• The microarray data were confirmed by qR-PCR and were compared with previously published experiments

• Approx. 4100 transcripts, corresponding to 35% of the expressed transcripts, showed ≥2-fold differences between the cartilage tissues in pairs
• Approx. 2% of the expressed genes were commonly expressed in the 4 pairs of samples
• Expression of some genes related to the metabolism, apoptosis, cell proliferation and matrix degradation activity was different in KBD cartilage vs normal

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