López P et al. – These findings suggest that the beneficial effect of antimalarials in low IL-10/high TNF-α patients with SLE may be partially attributable to the increase in regulatory T cell population (Treg) activity, whereas patients with the converse genotype did not show this phenomenon. Methods
Aim was to investigate the involvement of polymorphism in IL-10 and TNF-α genes in antimalarial treatment effects on cytokine serum levels and Treg in SLE pts
The alleles present at -308 TNF-α and -1082 IL-10 genes; serum concs of IFN-α, IL-10, and size and function of CD4+CD25high Treg population were determined in SLE pts and in healthy controls
These data were related to treatment and clinical manifestations
Results
Pts were observed to have increased IFN-α serum levels that did not correlate with any treatment
Among pts receiving antimalarial drugs, high IL-10/low TNF-α producers presented higher levels of IFN-α and IL-10 than carriers of other genotypes
Pts with low IL-10/high TNF-α genotype who were receiving antimalarial treatment presented increased size and function of Treg population
The percentage of CD4+CD25high cells was inversely correlated to TNF-α levels
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