Ngom G et al. - We report a case of SAPHO syndrome with pulmonary complications. A fifteen-year-old boy with a history of pustulosis presented with chronically swollen legs and left hemi thorax. The clinical presentation, the negative bacteriology, the lesions on radiology and the histology were in favour of the syndrome. Particularities of this case were pulmonary complications, cutaneous fistulas and a tibial fracture observed throughout the clinical course. The outcome was favourable after a treatment of non-steroidal anti-inflammatories.