Suzuki T et al. – This study provides evidence that the SNP A/G in the promoter region of the Tristetraprolin (TTP) gene mildly affects promoter activity, and thus, may influence the disease activity of inflammatory disorders including RA. Methods
TTP modulates the production of cytokines, including TNF-α
This study was conducted to investigate if the differences in TTP gene expression may affect the severity of inflammatory diseases, such as RA
Polymorphisms in the human TTP gene were searched
The entire TTP gene in 20 Japanese individuals (10 with RA and 10 healthy volunteers) were sequenced
Results
One single nucleotide polymorphism (SNP) in the promoter region was found
This SNP (A/G) was analysed by restriction fragment length polymorphism method in 155 RA pts and 100 control subjects
While the frequency of A allele in this SNP was similar in RA pts and controls the disease duration in RA pts with genotype GG was shorter than that of pts with genotypes AA/AG
RA pts with genotype GG had a higher probability of being treated with infliximab
The promoter activity of TTP promoter region with allele A was around two-fold higher than that with allele G
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