Chandran V et al. – The recurrence risk ratio for both PsA and psoriasis is high in FDRs and siblings of patients with PsA. These results confirm that both PsA and psoriasis have a strong heritable component. Methods
Study to determine the recurrence risk of psoriatic arthritis (PsA) and uncomplicated psoriasis in first degree relatives (FDRs) of pts with PsA
All available FDRs of 100 consecutive consenting pts were evaluated for the presence of psoriasis and PsA
The protocol included a screening questionnaire, physical examination by a rheumatologist, radiographic and laboratory assessment
Prevalence of PsA and Ps in FDRs of index case was determined and recurrence risk ratio was calculated
Results
The 100 probands had 533 relatives
84 of them were deceased and 53 were unavailable
Of the remaining 396 FDRs, 107 did not participate, thus, 73% of the available FDRs participated in the study
There were 130 siblings, 108 parents and 51 children
The prevalence of PsA and psoriasis among FDRs was 7.6% and 15.2%, respectively
The prevalence of PsA and psoriasis in siblings was 7.7% and 17.7%, respectively
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