Rheumatology Medical News about primary immunodefencies;osteoarticular infections

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Osteoarticular infectious complications in patients with primary immunodeficiencies
Current Opinion in Rheumatology, 06/11/08

Bloom KA et al. - Infectious arthritis is a significant comorbidity associated with primary immunodeficiencies and can be the presenting feature for some patients.

Methods

A review to describe the incidence and management of various infectious arthritides in selected primary immunodeficiency states

Results

Joint complications have been a well recognized finding in pts with primary immunodeficiencies for many yrs
Many are clearly infectious, but others apparently noninfectious similar to RA have been shown to be due to an underlying infectious trigger
In humoral immunodeficiencies, bacterial organisms are the most common causes, besides mycoplasmas and ureaplasmas
In nonhumoral immunodeficiencies, noninfectious inflammatory arthritides are more prevalent
Lack of appropriate culturing techniques and documentation of infectious agents may underestimate the prevalence of low-virulence infections in these pts

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