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immunosuppressive therapy in rheumatic diseases;tuberculosis reactivation Article Summary

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Tuberculosis reactivation during immunosuppressive therapy in rheumatic diseases: Diagnostic and therapeutic strategies.
Current Opinion in Rheumatology, 06/11/08
Print     Email This Article     Save in My Library   Free Abstract
Keane J et al. – Findings to date support the close screening and treatment for tumor necrosis factor in patients with autoimmune diseases. Such vigilance should probably be applied to future drugs that interfere with cytokines known to play a role in tuberculosis immunity.

Methods
  • Research that supports the screening and treatment of rheumatology pts with latent tuberculosis infection is reviewed, and the emerging consensus on how best to do this is discussed

Results
  • The limitations of testing to rule out latent tuberculosis infection in this group is emphasized, as this often prevents the tumor necrosis factor blocker prescriber from offering the patient complete reassurance with regard to tuberculosis risk

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