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Article Summary
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Aries PM et al. - This study does not support the assumption of a seasonal variation in the onset of Wegener's granulomatosis (WG) symptoms. In addition to some evidence for the association of silicate exposure and antineutrophil cytoplasmic antibody-associated vasculitides, the focus to collect more information about the pathogenesis of WG has been shifted to genetic associations like HLA-DPB*01 and PTPN22 Methods- A study to investigate the seasonal variation in WG symptoms in pathogenesis of the disease
- Data of 445 consecutive pts with WG in a monocentric cohort was evaluated
- 2 mos after diagnosis, the pts underwent a standardized evaluation with detailed questions about the time, type, and extent of initial symptoms
- The exact times of initial symptoms were then cross-checked by review of previous medical records
Results- A stable seasonal distribution of the initial symptoms over a period of 36 yrs w/o differences between seasons was observed
- Most frequent initial symptoms were ear, nose, and throat manifestations
- The unique advantage of the data presented is the validity of the information
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