rheumatologylinx Medical News about juvenile idiopathic arthritis;macrophage inflammatory protein 3

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juvenile idiopathic arthritis;macrophage inflammatory protein 3

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Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis
Arthritis & Rheumatism, 06/06/08

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Free Abstract

Bosco MC et al. - CCL20 is released into the SF of JIA patients, and SF monocytic cells are a major source of this chemokine. The hypoxic synovial microenvironment may directly contribute to the persistent inflammation associated with JIA by increasing CCL20 production by SF monocytic cells, thus representing a potential therapeutic target.

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