Galeotti L et al. – Circulating survivin is expressed in a significant group of patients with juvenile idiopathic arthritis (JIA) being associated to a severe course of the disease. This information may be used to select children with unfavorable prognosis of JIA who are in need of active pharmacologic treatment. Methods
Study to assess the presence of extracellular survivin in pts with JIA
Survivin levels were assessed in the circulation of 46 pts with JIA and in the age- and gender-matched controls (n=46) having no inflammatory disease, by ELISA
Survivin levels were analyzed with respect to the onset type and the activity of the joint disease
The intensity of inflammation and cartilage turnover was measured as levels of IL-6, serum amyloid A protein (SAA), and cartilage oligomeric matrix protein (COMP), respectively
Results
The levels of extracellular survivin were significantly higher in JIA vs controls
High levels of survivin were detected in 17% of JIA pts
High survivin expression was associated with polyarticular onset, active phase of arthritis
In contrast, survivin was neither related to the levels of IL-6, SAA, nor to COMP
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