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See Latest ArticlesAH amyloidosis associated with an immunoglobulin heavy chain variable region (VH1) fragment: a case report
Amyloid The Journal of Protein Folding Disorders, 05/23/08
Miyazaki D et al. - We report a 67-year-old male patient who suffered from nephrotic syndrome and progressive renal dysfunction with monoclonal gammopathy (IgMk). Renal biopsy demonstrated amyloid deposition in glomeruli. Biochemical analysis of the deposited amyloid fibrils in gastroduodenal mucosa revealed that the amyloid fibrils were composed of an immunoglobulin heavy chain variable region (VH) fragment belonging to the VH1 subgroup, and a diagnosis of AH amyloidosis was made. In our institute, three patients with AH amyloidosis including the present one have been identified during the past 2 years, so AH amyloidosis seems to be by no means a rare disorder.
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