Muntner P et al. – Metabolic syndrome and high body mass index in childhood were predictors of elevated uric acid in adulthood. Methods- Aim was to establish that metabolic syndrome is a risk factor for elevated serum uric acid
- Study participants (n=517) were examined as children, aged 5-17 yrs, and as adults 13-21 yrs later
- Childhood metabolic syndrome components included the highest quartile of BMI, insulin resistance, blood pressure, and triglycerides and lowest quartile of HDL cholesterol
- Metabolic syndrome was defined as the presence of 3 or more of these components and elevated serum uric acid, in adulthood
Results- For males, the odds ratios of elevated serum uric acid associated with high blood pressure, low HDL-cholesterol, high triglycerides, insulin resistance, and high BMI were 2.61 (1.13, 6.03), 1.47 (0.57, 3.80), 1.30 (0.55, 3.08), 2.87 (1.23, 6.71), and 3.25 (1.36, 7.74), respectively
- The analogous odds ratios for females were 2.12 (0.99, 4.54), 0.38 (0.14, 1.04), 1.16 (0.54, 2.46), 1.78 (0.83, 3.79), and 3.55 (1.73, 7.31), respectively
- Males and females with the metabolic syndrome in childhood were 2.60 (1.08, 6.27) and 3.01 (1.34, 6.75) times more likely to have elevated serum uric acid as adults, respectively
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