Kiani AN et al. – Inflammation, measured as ESR or hsCRP, is associated with coronary calcium only in univariate analyses. Age, BMI, and diabetes mellitus are more important associates of coronary calcium in SLE than inflammatory markers and SLE clinical activity. Methods
Study to assess the cardiovascular risk factors present in SLE pts and their correlation with coronary calcium
Coronary calcium was measured by helical computed in 200 pts with SLE enrolled in the Lupus Atherosclerosis Prevention Study
Patients had a mean age of 44.3 ± 11.4 yrs and were 92% women, 61% Caucasian, 34% African American, 2% Asian, and 2% Hispanic
Results
Coronary calcium was found in 43% of pts
Coronary calcification was associated with age, hypertension, BMI, ESR, anti-dsDNA, and lipoprotein(a)
Homocysteine, high-sensitivity C-reactive protein, and LDL, had a stronger association when considered as quantitative predictors
In a multiple logistic regression model, only age and BMI remained independent predictors
No measure of SLE activity was associated with coronary calcium
Based on a multiple logistic regression model, only age and diabetes mellitus remained significant independent predictors of coronary calcium > 100
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