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Article Summary
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Szodoray P et al. - Sjoumlgren's syndrome (SS) is characterized by a complex interplay of various cytokines and immune cells. The skewed T-cell subsets and cytokine imbalance play important roles in an orchestrated proinflammatory cascade. Methods- A study to describe how certain peripheral immune parameters reflect the inflammatory alterations in primary SS pts
- 49 pts with newly diagnosed pSS and 40 healthy individuals, all free from immunomodulant or immunosuppressive medication, were studied
- Peripheral blood lymphocyte subgroups were quantified by flow cytometry
- Soluble cytokines were assessed using ELISA
- Intracellular cytokine levels were measured after phorbol myristate acetate (PMA) stimulation by flow cytometry after staining of intracellular cytokines
Results- Pts with primary SS had higher percentages of activated CD3+/CD69+ T cells than controls
- When comparing naive vs memory subsets of CD4+ and CD8+ T cells, a shift towards the memory phenotype was observed for both
- Natural killer (NK) cell and NK T-cell (NKT) percentages and Th0 and Th1 cell numbers were increased in pts vs controls
- Among circulating cytokines, interferon (IFN)-γ was high, whereas interleukin (IL)-10 was decreased in SS vs controls
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