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See Latest ArticlesConstitutive STAT3 activation in peripheral CD3 + cells from patients with primary Sjögrens syndrome
Scandinavian Journal of Rheumatology , 05/22/08
Ramos HL et al. –Constitutive activation of STAT3 observed in primary Sjogren's syndrome (pSS) patients might not depend on cytokine stimulation but instead might be the result of an abnormal inactivation of pSTAT3.
Methods- Study to determine the pattern of STAT3 activation in peripheral lymphocytes from patients with pSS
- 12 pSS pts and 12 healthy age-matched control subjects were studied
- Peripheral blood mononuclear cells (PBMCs) were isolated by gradient centrifugation
- Phosphorylated STAT3 (pSTAT3) and also STAT3 expression were determined by flow cytometry in gated CD3+ and CD19+ lymphocytes
- Similarly, pJak1 and pTyk2 (the upstream activators of STAT3) were also determined in gated CD3+ lymphocytes
- Although the protein expression of STAT3 was similar, STAT3 was constitutively activated in CD3+ lymphocytes from pSS pts
- Neither Jak1 nor Tyk2 was activated in pSS CD3+ lymphocytes
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