Scheibel I et al. – In juvenile idiopathic arthritis (JIA), unlike in RA, CCR5Δ32 does not have a protective effect, but instead it could be a factor associated with more inflammatory forms of the disease. Methods
Study to determine whether the CCR5Δ32 polymorphism is associated with JIA and RA in Brazilian pts
203 RA pts, 101 JIA pts, and 104 healthy individuals were investigated by amplification of the CCR5Δ32 deletion
Allelic frequencies among these groups, as well as among different JIA subtypes were compared
Results
The frequency of the Δ32 allele was higher in JIA patients vs control subjects and RA pts
A higher CCR5Δ32 allelic frequency in the subtypes with a greater inflammatory component was observed: 4.1% in oligoarticular, 11.2% in polyarticular and 25% in systemic JIA
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