Düzgün N et al. – Distribution of thymidylate synthase (TYMS) genotype in Behçet's disease (BD) was not different from that of healthy controls. There was no relationship between TYMS genotype and the homocysteine levels in BD patients with thrombosis or without thrombosis. Methods
Aim was to assess whether TYMS genotype, serum homocysteine, and folate concentrations were related to venous thrombosis in BD pts
104 BD pts and 121 healthy individuals–controls
50/104 (48%) of pts had vascular involvement: 34 had active–history of venous thrombosis, 16 had arterial involvement, and 11 of these pts had both venous and arterial lesions
Genotype analysis of the TYMS promoter enhancer region was determined by PCR
Results
The distribution of the TYMS genotypes 2R/2R, 2R/3R, 3R/3R, 4R/2R, and 3R/3R were not different between BD pts and control group
TYMS genotypes were not associated with thrombosis and serum homocysteine concentration in BD pts
The mean serum homocysteine level in pts with thrombosis was higher than the level in pts w/o thrombosis
Serum folate concentrations were not different between the BD pts and the healthy controls
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