Janckila AJ et al. – Tartrate-resistant acid phosphatase (TRACP) isoforms could be useful disease markers in RA: TRACP-5a protein for systemic inflammatory macrophage burden and disease severity and TRACP-5b for osteoclast number and perhaps local or systemic bone destruction. Methods
Study to examine the significance of serum TRACP isoforms 5a and 5b as disease markers of inflammation and bone destruction in RA
118 pts: 50 with RA (25 with nodules), 26 with osteoarthritis (OA) and 42 with other rheumatic diseases vs 26 healthy adults
Serum TRACP-5a activity, TRACP-5a protein and TRACP-5b activity were determined by in-house immunoassays
C-reactive protein (CRP) was determined by in-house immunoassay
Other commercial markers included bone-specific alkaline phosphatase (bALP), C-telopeptides of type-I collagen (ICTP), cartilage glycoprotein-39 (YKL-40), and IgM rheumatoid factors (IgM-RF)
Results
Mean TRACP-5a protein was elevated only in RA vs healthy control and other disease groups
TRACP 5a protein correlated only with IgM-RF in RA
Among RA pts, mean TRACP 5a protein and IgM RF were higher in nodule formers
In contrast, TRACP-5b activity was slightly elevated in RA and correlated with bALP, ICTP and YKL-40, but not with IgM-RF or CRP
Mean TRACP-5b activity was no different in RA pts with or w/o nodules
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