Park MC et al. - Elevated urinary C-terminal telopeptide fragments of type I collagen (CTX-I) reflects disease activity and loss of femoral BMD while elevated CTX-II levels correlate well with radiographic damage of the spine, suggesting the usefulness of these markers for monitoring disease activity, loss of BMD, and radiographic damage in men with AS. Methods
Study to investigate association between the bone and cartilage turnover markers with disease activity, BMD, and radiographic damage of the spine in AS pts
35 men with newly diagnosed AS and 70 age-matched healthy men were enrolled
BMD of their lumbar spines and proximal femurs, Bath AS Disease Activity Index (BASDAI), and Bath AS Radiographic Index (BASRI) were evaluated
CTX-I and CTX-II levels were determined by ELISA, and serum levels of bone-specific alkaline phosphatase (BALP) and osteocalcin were determined by an enzyme immunoassay
Results
Pts with AS had higher mean urinary CTX-I and CTX-II levels than control subjects
Elevated urinary CTX-I levels correlated well with BASDAI, femoral BMD, and femoral T score
Elevated urinary CTX-II levels correlated well with spinal BASRI in pts with AS
Mean serum BALP and osteocalcin levels did not differ between pts and controls and did not show any correlations with BMD, BASDAI, or BASRI in men with AS
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