Mody S et al. - Greater age and worse physical function and health-related quality of life (HRQoL), but not pain severity, are predictive of non-opioid analgesics (NOA) use in symptomatic knee OA. Thus pain is not the primary determinant of NOA use over time among OA patients. Methods
Relationship of pain, physical function, and HRQoL to NOA use in symptomatic knee OA was assessed
NOA dose, pain, physical function, and HRQoL were evaluated for 1 yr
Doses provided by subjects' were normalized to equi-analgesic ibuprofen-equivalents (IEs)
Descriptive analyses at baseline, 1.5, and 12 mos
Non-parametric comparisons of NOA with pain, physical function, and HRQoL at 1.5 mos and over 12 mos
Results
71 subjects (19 males, 52 females; mean age:57 ± 10.5 yrs) used an average of 300 mg/wk of IE
25 subjects reported no analgesic use during the study
Of the 46 subjects that reported NOA use, the median intake was 1325 mg/wk IE
Age, Physical Functioning (PF) and HRQoL were predictive of NOA dose
Pain level was not predictive of NOA dose
The median NOA dose declined over 12 mos
However, this change was not associated with changes in PF, HRQoL or pain
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