Cadarette SM et al. - Differences in fracture risk between risedronate or raloxifene and alendronate were small. Nasal calcitonin recipients may have a higher risk for nonvertebral fractures compared with alendronate recipients. Methods
Aim was to compare the relative effectiveness of osteoporosis treatments to reduce nonvertebral fracture risk among older adults
43,135 new recipients of oral bisphosphonates, nasal calcitonin, and raloxifene
The mean age was 79 yrs, and 96% were women
The primary outcome was nonvertebral fracture within 12 mos of treatment initiation
Alendronate was the reference category in all analyses
Results
A total of 1051 nonvertebral fractures were observed within 12 mos
No large differences in fracture risk were found between risedronate or raloxifene and alendronate
Among those with a fracture history, raloxifene recipients experienced more nonvertebral fractures within 12 mos vs alendronate recipients
Pts who received calcitonin experienced more nonvertebral fractures than those who received alendronate
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