Ito T et al. – Adult-onset Still’s disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. This study describes the case of a patient with AOSD with severe liver dysfunction.
A 33-year-old with a 5-week history of intermittent fever (>39.0 °C), cervical lymphadenopathy, sore throat and polymyalgia
No evidence of infection
Salmon-pink eruptions that disappeared when his temperature was normalized were present on his anterior chest and extremities
The liver edge was palpable for 3 cm at the midclavicular line but not the spleen
His serum levels of IL-10 and 18 showed a similar trend to his disease activity
Drug lymphocyte stimulation tests were positive for three drugs
Hypercytokinaemia was controlled by plasma exchange therapy
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