Chung CP et al. –Only minor differences were found in the NMR lipid profiles of systemic lupus erythematosus (SLE) patients and controls. Lipoprotein subclasses were associated with metabolic variables, inflammatory markers, and corticosteroid use but not with coronary artery atherosclerosis. Methods
Hypothesis was that the size and number of lipoprotein particles may be better predictors of atherosclerosis
This hypothesis was tested in 105 pts with SLE and 77 control subjects
Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy (NMR)
Coronary artery calcification by electron beam computed tomography
Insulin resistance by homeostasis model assessment
Results
VLDL particles were larger and concentrations of large HDL particles lower in SLE pts
In SLE pts small LDL concentration was associated with BMI, insulin resistance, C-reactive protein, and erythrocyte sedimentation rate
Large HDL concentration was inversely associated with insulin resistance, disease activity, and ESR
VLDL concentrations correlated with CRP, ESR, disease damage, and corticosteroid exposure
Neither the concentration of lipoprotein subclasses nor particle size was associated with coronary artery atherosclerosis
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