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Article Summary
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Hofstee HMA et al. - Reduction of nailfold capillary density, but not capillary loop dimensions is associated with pulmonary arterial hypertension (PAH), and correlates with the severity of PAH in both SSc and IPAH. Methods- Study to investigate 1) the differences in capillary nailfold changes in SSc pts with and w/o PAH and 2) whether these changes are associated with PAH severity and disease specificity
- 21 healthy controls, 20 pts with IPAH, and 40 pts with SSc were enrolled
- 19/40 SSc pts had no PAH (SSc-nonPAH) and 21 had PAH (SScPAH), of whom 8 had PAH during exercise
Results- Capillary density was lower in SScPAH vs SSc-nonPAH pts, but loop dimensions were equal
- SScPAH pts had reduced capillary density and larger loop dimensions vs IPAH pts
- Capillary density in healthy controls was higher vs SSc-nonPAH SScPAH, and to IPAH
- No differences in capillary dimensions were present between healthy controls and IPAH
- Capillary density correlated with mean pulmonary arterial pressure at rest in SScPAH at rest, and IPAH
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