Damian-Abrego GN et al. - Patients with lupus deforming arthropathy had similar frequency of erosions and mean Sharp’s score than rhupus patients. Anti- cyclic citrullinated peptides (CCP) antibodies do not associate with lupus arthropathy, whether deforming, non-deforming or erosive. Methods
Association of Ab against anti-CCP in pts with lupus articular damage was studied
34 SLE pts with (n=14) or w/o (n=20) deforming arthropathy were studied
Anti-DNA and arthritis were mandatory inclusion criteria for both groups
As controls, 34 pts with RA and 9 pts with RA and systemic lupus erythematosus (rhupus) were included
Anti-CCP and RF were determined by ELISA and nephelometry respectively
All pts had recent x-ray films of the hands that were evaluated according to Sharp’s method
Results
SLE pts had a mean 6.50 ± 0.86 ACR criteria, RA pts met 5.38 ± 0.60 ACR criteria, and rhupus pts had 5.78 ± 0.44 criteria for RA and 5.11 ± 0.78 for SLE
SLE pts with or w/o deforming arthropathy, had normal serum anti-CCP concentrations
In contrast, RA and rhupus pts had 30- and 23-fold higher than normal amounts of anti-CCP
RA and rhupus pts were more frequently positive for anti-CCP than SLE pts with or w/o deforming arthropathy
Pts with lupus deforming arthropathy were more frequently positive for rheumatoid factor than pts with non-deforming arthritis
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