Tam LS et al. - PsA may be associated with obesity, hypertension, dyslipidaemia and insulin resistance because of the shared inflammatory pathway. Methods
Aim was to examine the distribution of traditional and novel risk factors of cardiovascular disease (CVD) in pts with PsA
Risk factors for CVD were compared between 102 consecutive PsA pts and 82 controls, adjusting for BMI
Role of inflammation on the CVD risk factor was also assessed by using a BMI and high-sensitivity CRP (hsCRP)-adjusted model
Results
The BMI of PsA pts were higher than healthy controls
After adjusting for the BMI, PsA pts had a higher prevalence of diabetes mellitus and hypertension but a lower prevalence of low HDL cholesterol
PsA pts had increased systolic and diastolic blood pressures, insulin resistance and inflammatory markers vs controls
PsA pts had higher HDL and apolipoprotein (Apo) A1 levels; and lower total cholesterol (TC) and LDL levels; and a lower TC/HDL ratio
However, the Apo B level, and the Apo B/Apo A1 ratio were higher in PsA pts
Adjustment for hsCRP level rendered the differences in the prevalence of hypertension and DM; the TC, and sugar levels; and white cell count non-significant between the two groups
Differences in other parameters remained significant
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