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serum uric acid levels;HbA1C and fasting glucose Article Summary

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Choi HK et al. - Individuals with moderately elevated haemoglobin A1c (HbA1c) may be at a higher risk of hyperuricaemia and gout, particularly in women, whereas individuals with diabetes or highly elevated HbA1c levels may be at a lower risk of these conditions, particularly in men.

Methods
  • An evaluation of HbA1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels in men and women
  • Data from 14,664 participants aged 20 yrs and older were collected and analyzed using multivariate linear regressions stratified by gender

Results
  • The serum uric acid levels increased with increasing serum HbA1c levels and thereafter decreased with further increasing HbA1c levels
  • Compared with a HbA1c level of <5%, the multivariate differences among women were 26.8 µmol/l for HbA1c of 6–6.9% and –25.6 µmol/l for HbA1c >=9%
  • The corresponding multivariate differences among men were 8.3 µmol/l and –64.8 µmol/l which were different from those among women
  • Fasting glucose levels also showed a bell-shaped relation with serum uric acid levels
  • Individuals with diabetes showed lower serum uric acid levels and the association was larger among men
  • Serum uric acid levels increased linearly with increasing fasting serum C-peptide levels, serum insulin levels or insulin resistance

 

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