Choi HK et al. - Individuals with moderately elevated haemoglobin A1c (HbA1c) may be at a higher risk of hyperuricaemia and gout, particularly in women, whereas individuals with diabetes or highly elevated HbA1c levels may be at a lower risk of these conditions, particularly in men. Methods
An evaluation of HbA1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels in men and women
Data from 14,664 participants aged 20 yrs and older were collected and analyzed using multivariate linear regressions stratified by gender
Results
The serum uric acid levels increased with increasing serum HbA1c levels and thereafter decreased with further increasing HbA1c levels
Compared with a HbA1c level of <5%, the multivariate differences among women were 26.8 µmol/l for HbA1c of 6–6.9% and –25.6 µmol/l for HbA1c >=9%
The corresponding multivariate differences among men were 8.3 µmol/l and –64.8 µmol/l which were different from those among women
Fasting glucose levels also showed a bell-shaped relation with serum uric acid levels
Individuals with diabetes showed lower serum uric acid levels and the association was larger among men
Serum uric acid levels increased linearly with increasing fasting serum C-peptide levels, serum insulin levels or insulin resistance
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