Bowers ME et al. - Although LiveWire offers repeatability and decreased segmentation time, manual segmentation more closely approximates true cartilage thickness, particularly in cartilage contact regions. Methods
A study to measure tibiofemoral (TF) cartilage thickness by employing both manual and LiveWire-based semi-automated segmentation methods
The articular cartilage of a cadaver knee and a healthy volunteer's knee were segmented manually and with LiveWire from multiple 3 T MR images
The cadaver specimen's cartilage thickness was also evaluated with a 3D laser scanner
Thickness measurements were made within specific cartilage regions
The reliability of each segmentation method was assessed both ex vivo and in vivo
Results
Mean coefficients of variation (CVs) of 4.16%, 3.02%, and 1.59%, were noted when evaluated with manual segmentation, LiveWire segmentation, and laser scanning, respectively
The cadaver specimen showed mean absolute errors vs laser scanning of 4.07% and 7.46% for manual and LiveWire segmentation, respectively
In vivo thickness measurements showed mean CVs of 2.71% and 3.65% when segmented manually and with LiveWire, respectively
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