Brien S et al. - No definitive conclusion could be drawn for either dimethyl sulfoxide (DMSO) or methylsulfonylmethane (MSM) supplements for their use in the treatment of mild to moderate OA of the knee. Methods
Review to evaluate the existing two chemically related nutritional supplements, DMSO and MSM in the treatment of OA to determine their efficacy and safety profile
The electronic databases were searched
Data were extracted and quality was assessed using the JADAD scale
Results
6 studies were included, evaluating 681 pts with OA of the knee for DMSO (N=297) on active treatment and 168 pts for MSM (N=52) on active treatment
2/4 DMSO trials, and both MSM trials reported improvement in pain outcomes in the treatment group vs comparator treatments
However, methodological issues and concerns over optimal dosage and treatment period, were highlighted
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