Zanchi C et al. – Calcium metabolism defects are common in untreated children with celiac disease (CD), and they returned to normal after gluten-free diet (GFD). Methods
A study to investigate the prevalence of both calcium metabolism alterations and bone defects in children with CD
54 untreated pts with CD (mean age: 7 yrs) were enrolled
Serum concentration of calcium, magnesium, 25(OH)vitamin D3, alkaline phosphatase, and parathyroid hormone (PTH) of CD pts were compared to 60 healthy children
Children with CD with 2 laboratory alterations underwent DEXA examination, which was evaluated after 6 mos of a gluten-free diet (GFD)
Results
The calcium and the 25(OH)vitamin D3 levels were lower in children with CD vs control subjects
PTH level was higher in children with CD vs control subjects
Hyperparathyroidism was found in 29 children with CD
20 pts tested positive for 2 laboratory alterations, and 10 of them were osteopenic
After 6 mos of GFD calcium, 25(OH)vit.D3 and PTH levels normalized, with the improvement of bone mineral density
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