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Article Summary
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Soylemezoglu O et al. - Genetic factors from HLA-DRB1 genotypes might be related to the susceptibility to Henoch-Schönlein purpura (HSP) for Turkish children but not to the severity of this disease. Methods- A study to investigate the implications of the HLA-DRB1 locus and the susceptibility to HSP
- Also to determine if there are associations with joint, gastrointestinal, and renal manifestations of the disease
- 110 Turkish pts with HSP were studied
- Pts and ethnically matched controls with respect to age and sex were HLA-DRB1 genotyped using molecular based methods
Results- HLA-DRB1 genotype differences between pts with HSP and controls were observed
- The frequency of HLA-DRB1*11/14 was higher and the frequency of HLA-DRB1*10/17 was lower in pts with HSP vs controls
- No HLA-DRB1 associations with gastrointestinal and renal manifestations were found
- In contrast, HLA-DRB1*11 positivity was increased and HLA-DRB1*14 positivity reduced in HSP pts with joint manifestations
- Also, HLA-DRB1*13 positivity was found to be increased in pts with nephrotic proteinuria
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