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Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Renal Failure, 03/28/08

Shalom R et al. - Hyperuricemia, generally defined as a plasma (or serum) urate concentration >7 mg/dL, has complications like gouty arthritis, nephrolithiasis, and urate or uric acid nephropathy. Allopurinol, or 4-hydroxypirazolo pyrimidine, an analog of xanthine, is used in the treatment of both primary and secondary hyperuricemia. Allopurinol is generally well tolerated, however a life-threatening toxicity syndrome AHS that includes vasculitis, rash, eosinophilia, hepatitis, and progressive renal failure is also described. The term DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome has been recently used to describe an entity presenting with similar features.

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